Despite targeting many critical pathways antibiotics have lost efficacy due to the evolution of resistance mechanisms in bacteria. Bacteria may evolve and learn to. How Bacteria Build Resistance At The Cellular Level Online Public Health Prescribers policymakers and researchers are. . What you need to know Medically reviewed by Daniel Murrell MD Antimicrobial resistance AMR or drug resistance develops when bacteria viruses or fungi stop responding. Dissemination of antibiotic resistance genes is an ecological and public health concern. This study discusses the impact of antibiotic resistance as a persistent global health threat and highlights efforts to improve this complex problem. Overuse of antibiotics has increased resistance in MRSA and other infectious bacteria because resistance genes the genes that code for resistance can be passed from bacteria to bacteria. There are three Domains and six Kingdoms under this syste...